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Transgene Detail
Symbol: Tg(tetO-DISC1*)1001Plet
Name: transgene insertion 1001, Mikhail Pletnikov
MGI ID: MGI:3838645
Synonyms: Tg(tetO/CMV-DISC1*)1001Plet, Tg(TRE-CMVhDISC1)
Transgene: Tg(tetO-DISC1*)1001Plet  Location: unknown  
Strain of Origin:  C57BL/6 and SJL
Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
Mutation:    Insertion
Tg(tetO-DISC1*)1001Plet expresses 1 gene
Mutation detailsThe transgene construct was designed with the myc peptide tagged mutant human DISC1 (disrupted in schizophrenia 1) gene, under the control of tetracycline operator (tetO; also called tetracycline-responsive element (TRE) or tet-operator) sequence and a cytomegalovirus minimal promoter. Founder line 1001, which showed strong expression, was established. A second line, line 70, shows weak expression of human DISC1. (J:146881)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:146881 Pletnikov MV, et al., Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia. Mol Psychiatry. 2008 Feb;13(2):173-86, 115
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
The Jackson Laboratory