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Fcgrttm1Esw
Targeted Allele Detail
Summary
Symbol: Fcgrttm1Esw
Name: Fc fragment of IgG receptor and transporter; targeted mutation 1, E Sally Ward
MGI ID: MGI:3838491
Synonyms: FcRnf
Gene: Fcgrt  Location: Chr7:44742417-44753246 bp, - strand  Genetic Position: Chr7, 29.12 cM
Alliance: Fcgrttm1Esw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:146640
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed neomycin cassette was placed upstream of exon 5 in a Hind-III restriction site, and a loxP site was placed downstream of exon 7 in a Bam-HI site. Correct targeting was confirmed by Southern blotting. Gene expression was unaffected as demonstrated by in situ staining of small intestine epithelial cells. (J:146640)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fcgrt Mutation:  60 strains or lines available
References
Original:  J:146640 Montoyo HP, et al., Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2788-93
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory