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Agpat2tm1Garg
Targeted Allele Detail
Nomenclature
Symbol: Agpat2tm1Garg
Name: 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta); targeted mutation 1, Abhimanyu Garg
MGI ID: MGI:3838346
Gene: Agpat2  Location: Chr2:26593057-26604417 bp, - strand  Genetic Position: Chr2, 18.96 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:146649
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsGenomic sequence spanning from upstream of exon 1 through exon 4 was replaced with a neo cassette. RT-PCR confirmed the absence of transcript expression. Enzymatic activity of the targeted protein is reduced to 10% of wild-type. (J:146649)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Agpat2 Mutation:  7 strains or lines available
References
Original:  J:146649 Cortes VA, et al., Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy. Cell Metab. 2009 Feb;9(2):165-76
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory