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Tg(Myh7-RARA/lacZ)30Mcco
Transgene Detail
Nomenclature
Symbol: Tg(Myh7-RARA/lacZ)30Mcco
Name: transgene insertion 30, Melissa C Colbert
MGI ID: MGI:3838149
Synonyms: beta-MyHC-hRARalpha-CB
Transgene: Tg(Myh7-RARA/lacZ)30Mcco  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Constitutively active, Humanized sequence, Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Tg(Myh7-RARA/lacZ)30Mcco expresses 1 gene
 
Mutation detailsThe mouse promoter was used to drive cardiac-specific expression of a human cDNA truncated at amino acid 448 and fused in frame via a collagen linker to lacZ. This truncation and fusion produces a constitutively active form. Two lines (30 and 32) were created. Line 30 has 12 copies of the transgene. (J:146424)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:146424 Colbert MC, et al., Cardiac compartment-specific overexpression of a modified retinoic acid receptor produces dilated cardiomyopathy and congestive heart failure in transgenic mice. J Clin Invest. 1997 Oct 15;100(8):1958-68
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory