Tg(Myh7-RARA/lacZ)30Mcco
Transgene Detail
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Symbol: |
Tg(Myh7-RARA/lacZ)30Mcco |
Name: |
transgene insertion 30, Melissa C Colbert |
MGI ID: |
MGI:3838149 |
Synonyms: |
beta-MyHC-hRARalpha-CB |
Transgene: |
Tg(Myh7-RARA/lacZ)30Mcco Location: unknown
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Alliance: |
Tg(Myh7-RARA/lacZ)30Mcco page
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Strain of Origin: |
Not Specified
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Transgene Type: |
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Transgenic (Constitutively active, Humanized sequence, Inserted expressed sequence, Reporter) |
Mutation: |
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Insertion
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Tg(Myh7-RARA/lacZ)30Mcco expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
RARA (5914) |
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Mutation details: The mouse promoter was used to drive cardiac-specific expression of a human cDNA truncated at amino acid 448 and fused in frame via a collagen linker to lacZ. This truncation and fusion produces a constitutively active form. Two lines (30 and 32) were created. Line 30 has 12 copies of the transgene.
(J:146424)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:146424 Colbert MC, et al., Cardiac compartment-specific overexpression of a modified retinoic acid receptor produces dilated cardiomyopathy and congestive heart failure in transgenic mice. J Clin Invest. 1997 Oct 15;100(8):1958-68 |
All: |
2 reference(s) |
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