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Targeted Allele Detail
Symbol: Pard3tm1.1Shoh
Name: par-3 family cell polarity regulator; targeted mutation 1.1, Shigeo Ohno
MGI ID: MGI:3838017
Synonyms: Par3deltaE3
Gene: Pard3  Location: Chr8:127063893-127612286 bp, + strand  Genetic Position: Chr8, 74.66 cM, cytoband E2
Germline Transmission:  Earliest citation of germline transmission: J:146415
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsGerm line, cre mediated recombination was used to remove the neo cassette and exon 3. Deletion of this exon results in a frame-shift mutation and premature termination in the CR1 domain. The absence of protein expression was confirmed by western blot analysis on E11.5 embryo extracts. (J:146415)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pard3 Mutation:  27 strains or lines available
Original:  J:146415 Hirose T, et al., PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains. Development. 2006 Apr;133(7):1389-98
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory