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Targeted Allele Detail
Symbol: Clic4tm1Jce
Name: chloride intracellular channel 4 (mitochondrial); targeted mutation 1, John C Edwards
MGI ID: MGI:3838012
Gene: Clic4  Location: Chr4:135213969-135272760 bp, - strand  Genetic Position: Chr4, 67.19 cM, cytoband D3
Germline Transmission:  Earliest citation of germline transmission: J:146487
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 2 was replaced with a self-excising neo and cre cassette via homologous recombination. Excision of the neo and cre cassette occurs on passage through the male germline leaving behind a single loxP site. RT-PCR and Western blot analysis confirmed the absence of intact transcript and protein expression in tissues from homozygous mice. (J:146487)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Clic4 Mutation:  36 strains or lines available
Original:  J:146487 Ulmasov B, et al., Chloride intracellular channel protein-4 functions in angiogenesis by supporting acidification of vacuoles along the intracellular tubulogenic pathway. Am J Pathol. 2009 Mar;174(3):1084-96
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.13
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