Isl1^tm1.2Whk
Targeted Allele Detail

Summary

• Symbol: Isl1^tm1.2Whk
• Name: ISL1 transcription factor, LIM/homeodomain; targeted mutation 1.2, William H Klein
• MGI ID: MGI:3837978
• Gene: Isl1 Location: Chr13:116434817-116446225 bp, - strand Genetic Position: Chr13, 64.87 cM, cytoband D2.3
• Alliance: Isl1^tm1.2Whk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146349
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre mediated recombination was used to remove exon 3, which contains the second essential LIM domain. (J:146349)

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Isl1 Mutation: 33 strains or lines available

References

• Original: J:146349 Mu X, et al., Gene regulation logic in retinal ganglion cell development: Isl1 defines a critical branch distinct from but overlapping with Pou4f2. Proc Natl Acad Sci U S A. 2008 May 13;105(19):6942-7
• All: 2 reference(s)