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Isl1tm1.2Whk
Targeted Allele Detail
Nomenclature
Symbol: Isl1tm1.2Whk
Name: ISL1 transcription factor, LIM/homeodomain; targeted mutation 1.2, William H Klein
MGI ID: MGI:3837978
Gene: Isl1  Location: Chr13:116298281-116309689 bp, - strand  Genetic Position: Chr13, 64.87 cM, cytoband D2.3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:146349
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsGerm line, cre mediated recombination was used to remove exon 3, which contains the second essential LIM domain. (J:146349)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Isl1 Mutation:  15 strains or lines available
References
Original:  J:146349 Mu X, et al., Gene regulation logic in retinal ganglion cell development: Isl1 defines a critical branch distinct from but overlapping with Pou4f2. Proc Natl Acad Sci U S A. 2008 May 13;105(19):6942-7
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory