Isl1^tm1.1Whk
Targeted Allele Detail

Summary

• Symbol: Isl1^tm1.1Whk
• Name: ISL1 transcription factor, LIM/homeodomain; targeted mutation 1.1, William H Klein
• MGI ID: MGI:3837972
• Synonyms: Isl1^flox
• Gene: Isl1 Location: Chr13:116434817-116446225 bp, - strand Genetic Position: Chr13, 64.87 cM, cytoband D2.3
• Alliance: Isl1^tm1.1Whk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146349
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and an frt flanked neo cassette with a 3' loxP site was inserted downstream of exon 3. Germ line, flp mediated recombination was used to remove the neo cassette. (J:146349)

Expression

In Mice Carrying this Mutation:	9 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Isl1 Mutation: 33 strains or lines available

References

• Original: J:146349 Mu X, et al., Gene regulation logic in retinal ganglion cell development: Isl1 defines a critical branch distinct from but overlapping with Pou4f2. Proc Natl Acad Sci U S A. 2008 May 13;105(19):6942-7
• All: 12 reference(s)