Cdx1^tm3Lhn
Targeted Allele Detail

Summary

• Symbol: Cdx1^tm3Lhn
• Name: caudal type homeobox 1; targeted mutation 3, David Lohnes
• MGI ID: MGI:3837942
• Synonyms: Cdx1^LRE+RARE
• Gene: Cdx1 Location: Chr18:61151934-61169271 bp, - strand Genetic Position: Chr18, 34.41 cM
• Alliance: Cdx1^tm3Lhn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146408
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The two Lef/Tcf-response elements and the retinoic acid-response element upstream of exon 1 were mutated, and a floxed neo cassette was inserted downstream of exon 1. Germ line, cre mediated recombination was used to remove the neo cassette. (J:146408)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdx1 Mutation: 13 strains or lines available

References

• Original: J:146408 Pilon N, et al., Wnt signaling is a key mediator of Cdx1 expression in vivo. Development. 2007 Jun;134(12):2315-23
• All: 1 reference(s)