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Targeted Allele Detail
Symbol: Tslptm1.1Pcn
Name: thymic stromal lymphopoietin; targeted mutation 1.1, Pierre Chambon
MGI ID: MGI:3837749
Synonyms: TslpL2
Gene: Tslp  Location: Chr18:32815383-32819799 bp, + strand  Genetic Position: Chr18, 18.12 cM
Germline Transmission:  Earliest citation of germline transmission: J:146511
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 2 and an frt flanked neo cassette with a 5' loxP site was inserted downstream of exon 4. Germ line, flp mediated recombination was used to remove the neo cassette leaving exons 2 through 4 floxed. (J:146511)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tslp Mutation:  2 strains or lines available
Original:  J:146511 Li M, et al., Induction of thymic stromal lymphopoietin expression in keratinocytes is necessary for generating an atopic dermatitis upon application of the active vitamin D3 analogue MC903 on mouse skin. J Invest Dermatol. 2009 Feb;129(2):498-502
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory