Ccm2^tm1.1Etl
Targeted Allele Detail

Summary

• Symbol: Ccm2^tm1.1Etl
• Name: cerebral cavernous malformation 2; targeted mutation 1.1, Elisabeth Tournier-Lasserve
• MGI ID: MGI:3837686
• Synonyms: Ccm2^-
• Gene: Ccm2 Location: Chr11:6496887-6546744 bp, + strand Genetic Position: Chr11, 4.45 cM
• Alliance: Ccm2^tm1.1Etl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146210
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A floxed GFP/hygromycin resistance cassette was placed upstream of exon 3 and an additional loxP site was placed downstream of exon 4. Chimeric mice were bred with Tg(rtetR-TetO-cre)40Mhz mice to remove the selection cassette and exons 3 and 4. Gene inactivation was confirmed by a lack of protein detected in immunoblot analysis of E9.5 embryo lysates. (J:146210)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccm2 Mutation: 47 strains or lines available

References

• Original: J:146210 Boulday G, et al., Tissue-specific conditional CCM2 knockout mice establish the essential role of endothelial CCM2 in angiogenesis: implications for human cerebral cavernous malformations. Dis Model Mech. 2009 Mar;2(3-4):168-77
• All: 2 reference(s)