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Pax6m1Lsli
Chemically induced Allele Detail
Summary
Symbol: Pax6m1Lsli
Name: paired box 6; mutant 1, Lingsong Li
MGI ID: MGI:3837670
Synonyms: Pax6m
Gene: Pax6  Location: Chr2:105499245-105527709 bp, + strand  Genetic Position: Chr2, 55.31 cM
Alliance: Pax6m1Lsli page
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsENU treatment generated an A to T transversion that led to the amino acid substitution of a STOP codon for arginine at position 266 (R266X). This allele produces a truncated protein at amino acid 266. (J:146325)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pax6 Mutation:  90 strains or lines available
References
Original:  J:146325 Wen JH, et al., Paired box 6 (PAX6) regulates glucose metabolism via proinsulin processing mediated by prohormone convertase 1/3 (PC1/3). Diabetologia. 2009 Mar;52(3):504-13
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory