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Gene trapped Allele Detail
Symbol: Trim32Gt(BGA355)Byg
Name: tripartite motif-containing 32; gene trap BGA355, BayGenomics
MGI ID: MGI:3837468
Gene: Trim32  Location: Chr4:65604986-65616238 bp, + strand  Genetic Position: Chr4, 34.43 cM, cytoband C1
Mutant Cell Line:  BGA355 (BayGenomics)
Germline Transmission:  Earliest citation of germline transmission: J:146155
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Gene trapped
Mutation:    Insertion of gene trap vector     Vector: pGT1Lxf     Vector Type: gene trap
Mutation detailsThe gene trap vector, containing a beta-geo cassette, inserted at nucleotide 410 within exon 2. The absence of transcript expression was confirmed by RT-PCR analysis on brain extracts. Note transcript expression of the flanking gene is normal as confirmed by RT-PCR analysis on brain and skeletal muscle extracts. (J:146155)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
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View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trim32 Mutation:  4 strains or lines available
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

Original:  J:146155 Kudryashova E, et al., Deficiency of the E3 ubiquitin ligase TRIM32 in mice leads to a myopathy with a neurogenic component. Hum Mol Genet. 2009 Apr 1;18(7):1353-67
All:  5 reference(s)

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