Ptgs2^tm1Wlf
Targeted Allele Detail

Summary

• Symbol: Ptgs2^tm1Wlf
• Name: prostaglandin-endoperoxide synthase 2; targeted mutation 1, Clifford J Woolf
• MGI ID: MGI:3837433
• Synonyms: Cox2^fl
• Gene: Ptgs2 Location: Chr1:149975851-149983978 bp, + strand Genetic Position: Chr1, 63.84 cM, cytoband H1
• Alliance: Ptgs2^tm1Wlf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146193
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion LoxP sites were inserted upstream of exon 6 and downstream of exon 8. (J:146193)

Generation of the Ptgs2^tm1Wlf allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptgs2 Mutation: 72 strains or lines available

References

• Original: J:146193 Vardeh D, et al., COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice. J Clin Invest. 2009 Feb;119(2):287-94
• All: 3 reference(s)