Lrp5^{tm3(Lrp5*)Kry}
Targeted Allele Detail

Summary

• Symbol: Lrp5^{tm3(Lrp5*)Kry}
• Name: low density lipoprotein receptor-related protein 5; targeted mutation 3, Gerard Karsenty
• MGI ID: MGI:3837395
• Gene: Lrp5 Location: Chr19:3634828-3736564 bp, - strand Genetic Position: Chr19, 3.33 cM, cytoband B
• Alliance: Lrp5^{tm3(Lrp5*)Kry} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146078
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in exon 1 just in front of the ATG start site and a floxed neo cassette and cDNA containing a mutant form of Lrp5 with a flag tag were inserted in intron 1. The cDNA included 2 mutations 5 glycine and 171 valine. The neo cassette was later removed by Cre mediated recombination. (J:146078)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrp5 Mutation: 81 strains or lines available

References

• Original: J:146078 Yadav VK, et al., Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell. 2008 Nov 28;135(5):825-37
• All: 2 reference(s)