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Dhx58tm1Gnb
Targeted Allele Detail
Nomenclature
Symbol: Dhx58tm1Gnb
Name: DEXH (Asp-Glu-X-His) box polypeptide 58; targeted mutation 1, Glen N Barber
MGI ID: MGI:3837303
Synonyms: Lgp2-
Gene: Dhx58  Location: Chr11:100694884-100704271 bp, - strand  Genetic Position: Chr11, 63.52 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:146113
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 through 6 were replaced with a floxed neo cassette. The absence of protein expression following treatment with IFN-beta was confirmed by western blot analysis on mouse embryo fibroblasts. (J:146113)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dhx58 Mutation:  16 strains or lines available
References
Original:  J:146113 Venkataraman T, et al., Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses. J Immunol. 2007 May 15;178(10):6444-55
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory