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Lmnatm4Lgf
Targeted Allele Detail
Nomenclature
Symbol: Lmnatm4Lgf
Name: lamin A; targeted mutation 4, Loren G Fong
MGI ID: MGI:3837135
Synonyms: LmnaggHG
Gene: Lmna  Location: Chr3:88480147-88509956 bp, - strand  Genetic Position: Chr3, 38.84 cM
Rib fractures in Lmnatm4Lgf/Lmna+ and Lmnatm1Lgf/Lmna+ mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:146099
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion, Single point mutation
 
Mutation detailsIntrons 10 and 11 and the last 150 nucleotides of exon 11 were deleted, thereby abolishing production of lamin C and producing a mutated prelamin A that precludes wild-type Lmna synthesis. A point mutation in exon 12 resulted in the amino acid substitution of leucine for methionine within the CaaX motif. This substitution triggers protein geranylgeranylation. A floxed neo cassette downstream of exon 12 was used for selection. (J:146099)
Generation of the Lmnatm4Lgf allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lmna Mutation:  67 strains or lines available
References
Original:  J:146099 Davies BS, et al., Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome. J Lipid Res. 2009 Jan;50(1):126-34
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/05/2018
MGI 6.12
The Jackson Laboratory