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Targeted Allele Detail
Symbol: Lmnatm4Lgf
Name: lamin A; targeted mutation 4, Loren G Fong
MGI ID: MGI:3837135
Synonyms: LmnaggHG
Gene: Lmna  Location: Chr3:88480147-88509956 bp, - strand  Genetic Position: Chr3, 38.84 cM
Rib fractures in Lmnatm4Lgf/Lmna+ and Lmnatm1Lgf/Lmna+ mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:146099
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion, Single point mutation
Mutation detailsIntrons 10 and 11 and the last 150 nucleotides of exon 11 were deleted, thereby abolishing production of lamin C and producing a mutated prelamin A that precludes wild-type Lmna synthesis. A point mutation in exon 12 resulted in the amino acid substitution of leucine for methionine within the CaaX motif. This substitution triggers protein geranylgeranylation. A floxed neo cassette downstream of exon 12 was used for selection. (J:146099)
Generation of the Lmnatm4Lgf allele
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lmna Mutation:  56 strains or lines available
Original:  J:146099 Davies BS, et al., Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome. J Lipid Res. 2009 Jan;50(1):126-34
All:  1 reference(s)

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