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Targeted Allele Detail
Symbol: Thrbtm1Mkni
Name: thyroid hormone receptor beta; targeted mutation 1, Marlies Knipper
MGI ID: MGI:3836780
Synonyms: TRbeta L2, TRbetalox
Gene: Thrb  Location: Chr14:17660960-18038086 bp, + strand  Genetic Position: Chr14, 7.08 cM, cytoband A3
Germline Transmission:  Earliest citation of germline transmission: J:145941
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsLoxP sites were introduced 5' and 3' of exon 5 and an frt-flanked neo cassette was introduced downstream of the 3' loxP site via homologous recombination. The neo cassette was then removed by FLP mediated recombination leaving behind a single frt site. (J:145941)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Thrb Mutation:  15 strains or lines available
Original:  J:145941 Winter H, et al., Deafness in TRbeta mutants is caused by malformation of the tectorial membrane. J Neurosci. 2009 Feb 25;29(8):2581-7
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
The Jackson Laboratory