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Kcnk10tm1Fles
Targeted Allele Detail
Nomenclature
Symbol: Kcnk10tm1Fles
Name: potassium channel, subfamily K, member 10; targeted mutation 1, Florian Lesage
MGI ID: MGI:3836779
Synonyms: TREK2-
Gene: Kcnk10  Location: Chr12:98429432-98578213 bp, - strand  Genetic Position: Chr12, 49.86 cM, cytoband F1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:145944
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsGene gap repair was used to duplicate exon 2 and inserted a neo cassette between the two copies of exon 2. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:145944)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnk10 Mutation:  3 strains or lines available
References
Original:  J:145944 Guyon A, et al., Glucose inhibition persists in hypothalamic neurons lacking tandem-pore K+ channels. J Neurosci. 2009 Feb 25;29(8):2528-33
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory