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Egr2tm2Jmi
Targeted Allele Detail
Nomenclature
Symbol: Egr2tm2Jmi
Name: early growth response 2; targeted mutation 2, Jeffrey Milbrandt
MGI ID: MGI:3836632
Synonyms: Egr2I26N
Gene: Egr2  Location: Chr10:67535475-67542188 bp, + strand  Genetic Position: Chr10, 34.96 cM, cytoband B5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:145949
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Single point mutation
 
Mutation detailsA point mutation was used to engineer the amino acid substitution of asparagine for isoleucine at position 268 (I268N). A floxed neo cassette was inserted into the intron upstream of the point mutation and was removed by germ line, cre mediated recombination. (J:145949)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Egr2 Mutation:  18 strains or lines available
References
Original:  J:145949 Baloh RH, et al., Congenital hypomyelinating neuropathy with lethal conduction failure in mice carrying the Egr2 I268N mutation. J Neurosci. 2009 Feb 25;29(8):2312-21
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory