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Targeted Allele Detail
Symbol: Cdc25atm1Hpw
Name: cell division cycle 25A; targeted mutation 1, Helen Piwnica-Worms
MGI ID: MGI:3836585
Synonyms: Af, Cdc25Af
Gene: Cdc25a  Location: Chr9:109875579-109893895 bp, + strand  Genetic Position: Chr9, 59.81 cM
Germline Transmission:  Earliest citation of germline transmission: J:145768
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was introduce 5' of exon 1 and a loxP-flanked selection cassette was introduced to intron 3 via 129X1/SvJ-derived RW4 embryonic stem (ES) cells. ES cell clones containing the recombinant allele were expanded and transiently transfected with aplasmid encoding Cre recombinase under the control of the CMV promoter to remove the selection cassette, but leave floxed exons 1-3. (J:145768)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdc25a Mutation:  12 strains or lines available
Original:  J:145768 Lee G, et al., Response of small intestinal epithelial cells to acute disruption of cell division through CDC25 deletion. Proc Natl Acad Sci U S A. 2009 Mar 9;
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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