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Targeted Allele Detail
Symbol: Cdc25atm1Hpw
Name: cell division cycle 25A; targeted mutation 1, Helen Piwnica-Worms
MGI ID: MGI:3836585
Synonyms: Af, Cdc25Af
Gene: Cdc25a  Location: Chr9:109875579-109893895 bp, + strand  Genetic Position: Chr9, 59.81 cM
Germline Transmission:  Earliest citation of germline transmission: J:145768
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was introduce 5' of exon 1 and a loxP-flanked selection cassette was introduced to intron 3 via 129X1/SvJ-derived RW4 embryonic stem (ES) cells. ES cell clones containing the recombinant allele were expanded and transiently transfected with a plasmid encoding Cre recombinase under the control of the CMV promoter to remove the selection cassette, but leave floxed exons 1-3. (J:145768)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdc25a Mutation:  14 strains or lines available
Original:  J:145768 Lee G, et al., Response of small intestinal epithelial cells to acute disruption of cell division through CDC25 deletion. Proc Natl Acad Sci U S A. 2009 Mar 9;
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
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