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Xrcc1tm1Pmc
Targeted Allele Detail
Nomenclature
Symbol: Xrcc1tm1Pmc
Name: X-ray repair complementing defective repair in Chinese hamster cells 1; targeted mutation 1, Peter J McKinnon
MGI ID: MGI:3836442
Synonyms: Xrcc1c
Gene: Xrcc1  Location: Chr7:24546704-24573438 bp, + strand  Genetic Position: Chr7, 11.42 cM, cytoband A3-B2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:145730
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed neo cassette was inserted upstream of exon 4 and a loxP site was inserted downstream of exon 10. Transient cre mediated recombination in ES cells removed the neo cassette leaving exons 4 through 10 floxed. (J:152528)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Xrcc1 Mutation:  34 strains or lines available
References
Original:  J:145730 Reynolds JJ, et al., Defective DNA ligation during short-patch single-strand break repair in ataxia oculomotor apraxia 1. Mol Cell Biol. 2009 Mar;29(5):1354-62
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory