Tg(Cdh5-cre)1Spe
Transgene Detail

Summary

• Symbol: Tg(Cdh5-cre)1Spe
• Name: transgene insertion 1, Nancy A Speck
• MGI ID: MGI:3836418
• Synonyms: Cdh5-cre, VECad-Cre, VEC-Cre
• Transgene: Tg(Cdh5-cre)1Spe Location: unknown
• Alliance: Tg(Cdh5-cre)1Spe page

Transgene origin

• Strain of Origin: (C57BL/6J x 129S1/SvImJ)F1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Cdh5-cre)1Spe expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Cdh5

• Mutation details: 2.5 Kb of the Cdh5 promoter was fused to a cre recombinase gene and placed between two genomic insulators derived from the chicken gamma-globulin gene. When crossed with cre-reporter strains, cre expression was detected in the yolk sac and vasculature of E9.5-E10.5 conceptus, and in the liver of E15.5 fetuses. Nearly all adult blood cells from mice carrying this transgene are derived from progentiors that have expressed cre. (J:145700)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cdh5 (species not specified) Summary of all recombinase alleles driven by Cdh5. Comparative matrix view of recombinase activities

Expression

In Mice Carrying this Mutation:

8 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:145700 Chen MJ, et al., Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter. Nature. 2009 Feb 12;457(7231):887-91
• All: 59 reference(s)