About   Help   FAQ
Tg(Cdh5-cre)1Spe
Transgene Detail
Nomenclature
Symbol: Tg(Cdh5-cre)1Spe
Name: transgene insertion 1, Nancy A Speck
MGI ID: MGI:3836418
Synonyms: Cdh5-cre, VECad-Cre, VEC-Cre
Transgene: Tg(Cdh5-cre)1Spe  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6J x 129S1/SvImJ)F1
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation details2.5 Kb of the Cdh5 promoter was fused to a cre recombinase gene and placed between two genomic insulators derived from the chicken gamma-globulin gene. When crossed with cre-reporter strains, cre expression was detected in the yolk sac and vasculature of E9.5-E10.5 conceptus, and in the liver of E15.5 fetuses. Nearly all adult blood cells from mice carrying this transgene are derived from progentiors that have expressed cre. (J:145700)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Cdh5     Summary of all recombinase alleles driven by Cdh5.
 

Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
References
Original:  J:145700 Chen MJ, et al., Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter. Nature. 2009 Feb 12;457(7231):887-91
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2019
MGI 6.14
The Jackson Laboratory