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Targeted Allele Detail
Symbol: Cacna1atm3Maag
Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit; targeted mutation 3, Arn van den Maagdenberg
MGI ID: MGI:3836195
Synonyms: Cacna1aS218L, Cacna1atm1Caya, FHM-1
Gene: Cacna1a  Location: Chr8:84388440-84640246 bp, + strand  Genetic Position: Chr8, 40.95 cM
Neurological deficits after spreading depression in Cacna1atm1Maag/Cacna1atm1Maag and Cacna1atm3Maag/Cacna1atm3Maag mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:144701
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Single point mutation
Mutation detailsA transition of C to T results in the amino acid substitution of leucine for serine at position 218 (S218L), replicating a mutation found in some familial hemiplegic migraine type 1 (FHM1) patients. A floxed neo cassette inserted upstream of exon 5 was removed by germ line, cre mediated recombination. (J:144701, J:211767)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cacna1a Mutation:  71 strains or lines available
Original:  J:144701 Eikermann-Haerter K, et al., Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1. J Clin Invest. 2009 Jan;119(1):99-109
All:  10 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory