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Tg(MMTV-AURKA)#Cxd
Transgene Detail
Nomenclature
Symbol: Tg(MMTV-AURKA)#Cxd
Name: transgene insertion, Chu-Xia Deng
MGI ID: MGI:3836060
Synonyms: MMTV-Aurora-A
Transgene: Tg(MMTV-AURKA)#Cxd  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(MMTV-AURKA)#Cxd expresses 1 gene
 
Mutation detailsThe coding sequence for the human AURKA gene (Aurora-A) was placed under the control of the mouse mammary tumor virus enhancer and promoter. Six founder lines were established using the transgene construct with the two highest expressing lines pooled for phenotypic analysis. Transgene expression for both lines was highestin the mammary and salivary glands, followed by (in descending order of expression) kidney, spleen, liver, brain, and uterus. (J:145680)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:145680 Wang X, et al., Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation. Oncogene. 2006 Nov 16;25(54):7148-58
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/17/2015
MGI 5.21
The Jackson Laboratory