Glud1^tm1.1Pma
Targeted Allele Detail

Summary

• Symbol: Glud1^tm1.1Pma
• Name: glutamate dehydrogenase 1; targeted mutation 1.1, Pierre Maechler
• MGI ID: MGI:3835667
• Synonyms: Glud1^lox
• Gene: Glud1 Location: Chr14:34032684-34066990 bp, + strand Genetic Position: Chr14, 20.8 cM
• Alliance: Glud1^tm1.1Pma page

Glud1^tm1.1Pma/Glud1^tm1.1Pma Tg(Ins2-cre)23Herr/0 mice have impaired insulin secretion

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145558
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 7 and an frt-flanked neo cassette with a 5' loxP site was inserted downstream of exon 7. Germ line, flp mediated recombination removed the neo cassette leaving exon 7 floxed. (J:145558)

Generation of the conditional Glud1^tm1.1Pma allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Glud1 Mutation: 38 strains or lines available

References

• Original: J:145558 Carobbio S, et al., Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis. J Biol Chem. 2009 Jan 9;284(2):921-9
• All: 13 reference(s)