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Transgene Detail
Symbol: Tg(TcraTcrbAD10)1Hed
Name: transgene insertion 1, Stephen M Hedrick
MGI ID: MGI:3835444
Synonyms: AD10
Transgene: Tg(TcraTcrbAD10)1Hed  Location: unknown  
Strain of Origin:  (C57BL/6 x SJL)F2
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(TcraTcrbAD10)1Hed expresses 2 genes
Mutation detailsProductively rearranged Tcra and Tcrb genes were cloned from the murine T cell clone AD10 that is specific for pigeon cytochrome-c. In mice expressing I-Ek, or I-Eb, greater than 90% of thymocytes and T cells express the transgenic TCR. The alpha-chain of this transgenic TCR differs by one amino acid (a threonine instead of an alanine at position 99) to the alpha chain of the transgenic TCR expressed in Tg(TcrAND)53Hed transgenic mice. (J:124701)
View phenotypes and curated references for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:124701 Kaye J, et al., Involvement of the same region of the T cell antigen receptor in thymic selection and foreign peptide recognition. J Immunol. 1992 Jun 1;148(11):3342-53
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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