Tg(TcraTcrbAD10)1Hed
Transgene Detail

Summary

• Symbol: Tg(TcraTcrbAD10)1Hed
• Name: transgene insertion 1, Stephen M Hedrick
• MGI ID: MGI:3835444
• Synonyms: AD10
• Transgene: Tg(TcraTcrbAD10)1Hed Location: unknown
• Alliance: Tg(TcraTcrbAD10)1Hed page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(TcraTcrbAD10)1Hed expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)
  mouse	Tcrb (MGI:98578)

• Mutation details: Productively rearranged Tcra and Tcrb genes were cloned from the murine T cell clone AD10 that is specific for pigeon cytochrome-c. In mice expressing I-E^k, or I-E^b, greater than 90% of thymocytes and T cells express the transgenic TCR. The alpha-chain of this transgenic TCR differs by one amino acid (a threonine instead of an alanine at position 99) to the alpha chain of the transgenic TCR expressed in Tg(TcrAND)53Hed transgenic mice. (J:124701)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:124701 Kaye J, et al., Involvement of the same region of the T cell antigen receptor in thymic selection and foreign peptide recognition. J Immunol. 1992 Jun 1;148(11):3342-53
• All: 12 reference(s)