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Tg(tetO-BRAF*V600E)29Lc
Transgene Detail
Summary
Symbol: Tg(tetO-BRAF*V600E)29Lc
Name: transgene insertion 29, Lynda Chin
MGI ID: MGI:3834721
Synonyms: Tet-BRAF*
Transgene: Tg(tetO-BRAF*V600E)29Lc  Location: unknown  
Alliance: Tg(tetO-BRAF*V600E)29Lc page
Transgene
origin
Strain of Origin:  Not Applicable
Transgene
description
Transgene Type:    Transgenic (Constitutively active, Humanized sequence, Inducible, Inserted expressed sequence)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
 
Tg(tetO-BRAF*V600E)29Lc expresses 1 gene
 
Mutation detailsThe tetracycline operon was used to drive inducible expression of a human cDNA with nucleotide substitutions that result in the amino acid substitution of glutamic acid for valine at position 600 (V600E). This mutation creates a constitutively active form. Two lines were created (lines 29 and 13). Line 29 was selected as the representative line. (J:144358)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:144358 Jeong JH, et al., BRAF activation initiates but does not maintain invasive prostate adenocarcinoma. PLoS One. 2008;3(12):e3949
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory