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Tg(SFTPC-EML4/ALK)502-4Hima
Transgene Detail
Nomenclature
Symbol: Tg(SFTPC-EML4/ALK)502-4Hima
Name: transgene insertion 502-4, Hiroyuki Mano
MGI ID: MGI:3834680
Synonyms: EML4-ALK
Transgene: Tg(SFTPC-EML4/ALK)502-4Hima  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6J
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(SFTPC-EML4/ALK)502-4Hima expresses 2 genes
 
Mutation detailsThe human SFTPC promoter was used to drive lung-specific expression of a flag-tagged human fusion generated in human non-small-cell lung cancer due to recurrent chromosome inversion, inv(2)(p21p23). Two lines were created (502-4 and 501-3) that exhibit identical tumor-forming activity. Line 502-4 was selected as the representative line. Line 502-4 carried 30 copies of the transgene. (J:142679)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:142679 Soda M, et al., A mouse model for EML4-ALK-positive lung cancer. Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19893-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory