Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer
Transgene Detail

Summary

• Symbol: Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer
• Name: transgene insertion VF1-07, Maria Eriksson
• MGI ID: MGI:3834666
• Synonyms: tetop-LA^G608G
• Transgene: Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer Location: unknown
• Alliance: Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence, Reporter)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LMNA (4000)

  Lmna	(MGI:96794)

• Mutation details: The human gene from a patient with Hutchinson-Gilford progeria syndrome, in which a nucleotide substitution (1824C>T; G608G) activates a cryptic splice site, was inserted downstream of a tetracycline promoter and upstream of an IRES-EGFP. Eight lines were created. (J:145312)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:145312 Sagelius H, et al., Targeted transgenic expression of the mutation causing Hutchinson-Gilford progeria syndrome leads to proliferative and degenerative epidermal disease. J Cell Sci. 2008 Apr 1;121(Pt 7):969-78
• All: 12 reference(s)