About   Help   FAQ
Kdm1atm1.2Tche
Targeted Allele Detail
Nomenclature
Symbol: Kdm1atm1.2Tche
Name: lysine (K)-specific demethylase 1A; targeted mutation 1.2, Taiping Chen
MGI ID: MGI:3834630
Synonyms: Aof21lox
Gene: Kdm1a  Location: Chr4:136550540-136602723 bp, - strand  Genetic Position: Chr4, 68.8 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:144527
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsGerm line, cre mediated recombination was used to remove exons 10 through 13 leading to a frame shift. The absence of protein expression was confirmed by western blot analysis on embryonic stem cells. (J:144527)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kdm1a Mutation:  30 strains or lines available
References
Original:  J:144527 Wang J, et al., The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation. Nat Genet. 2009 Jan;41(1):125-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/15/2018
MGI 6.12
The Jackson Laboratory