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Hbb-ytm2.2Fier
Targeted Allele Detail
Nomenclature
Symbol: Hbb-ytm2.2Fier
Name: hemoglobin Y, beta-like embryonic chain; targeted mutation 2.2, Steven Fiering
MGI ID: MGI:3834620
Synonyms: deltaEy(inv)
Gene: Hbb-y  Location: Chr7:103851749-103853216 bp, - strand  Genetic Position: Chr7, 54.85 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:145362
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion, Inversion
  Hbb-ytm2.2Fier involves 3 genes/genome features (Hbb-bh1, Hbb-bh0, Hbb-y) View all
 
Mutation details1.1 kb of DNA containing the promoter region, exon1, and exon2 was replaced with a floxed PGK-hygro selection cassette in ES cells already containing the targeted allele Hbb-bh1 allele. The selection cassettes in the two genes were subsequently excised by breeding mice to CMV-cre transgenic mice. Because the two loxP sites left behind are in reverse orientation to one another, cre also induced an inversion of the DNA segment between the two sites. This allele is only found in conjunction with Hbb-bh1. (J:145362)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hbb-y Mutation:  1 strain or line available
References
Original:  J:145362 Hu X, et al., Transcriptional interference among the murine beta-like globin genes. Blood. 2007 Mar 1;109(5):2210-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory