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Tg(Ly6a-TK,-BCR/ABL1)IS9AIsg
Transgene Detail
Nomenclature
Symbol: Tg(Ly6a-TK,-BCR/ABL1)IS9AIsg
Name: transgene insertion IS9A, Isidro Sanchez-Garcia
MGI ID: MGI:3834479
Synonyms: IS9A
Transgene: Tg(Ly6a-TK,-BCR/ABL1)IS9AIsg  Location: unknown  
Transgene
origin
Strain of Origin:  (CBA x C57BL/6J)
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Ly6a-TK,-BCR/ABL1)IS9AIsg expresses 2 genes
 
Mutation detailsThe promoter was used to drive hematopoietic stem cell-specific expression of a human thymidine kinase and BCR-ABL1p210 fusion separated by an IRES. One line was created (IS9A). (J:144382)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:144382 Perez-Caro M, et al., Cancer induction by restriction of oncogene expression to the stem cell compartment. EMBO J. 2009 Jan 7;28(1):8-20
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory