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Tg(tetO-PIK3CA*H1047R)13Lca
Transgene Detail
Nomenclature
Symbol: Tg(tetO-PIK3CA*H1047R)13Lca
Name: transgene insertion 13, Lewis C Cantley
MGI ID: MGI:3834439
Synonyms: p110-alpha H1047R
Transgene: Tg(tetO-PIK3CA*H1047R)13Lca  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inducible, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(tetO-PIK3CA*H1047R)13Lca expresses 1 gene
 
Mutation detailsThe tetracyclin operator was used to drive expression of the human cDNA with a point mutation that results in the amino acid substitution of arginine for histidine at position 1047 (H1047R). Three lines were generated (13, 121 and 3011). Line 13 carries around 20 copies of the transgene compared to around 60 in line 121. (J:142254)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:142254 Engelman JA, et al., Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med. 2008 Dec;14(12):1351-6
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory