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Targeted Allele Detail
Symbol: Mbl1tm1Rala
Name: mannose-binding lectin (protein A) 1; targeted mutation 1, Rachel A Lawrence
MGI ID: MGI:3834180
Synonyms: MBL-A-
Gene: Mbl1  Location: Chr14:41151456-41158959 bp, + strand  Genetic Position: Chr14, 22.36 cM
Germline Transmission:  Earliest citation of germline transmission: J:145279
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 2 kb region containing exons 2 and 3 which encode the translationb start site and the collagenous domain was replaced with a neomycin resistance cassette inserted in reverse orientation. Northern blot and Western blot analyses confirmed the absence of mRNA and of protein product. (J:145279)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mbl1 Mutation:  15 strains or lines available
Original:  J:145279 Carter T, et al., Mannose-binding lectin A-deficient mice have abrogated antigen-specific IgM responses and increased susceptibility to a nematode infection. J Immunol. 2007 Apr 15;178(8):5116-23
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
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