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Targeted Allele Detail
Symbol: Gng7tm2(cre/PGR)Mmsh
Name: guanine nucleotide binding protein (G protein), gamma 7; targeted mutation 2, Masayoshi Mishina
MGI ID: MGI:3833956
Synonyms: Gng7mCrePR
Gene: Gng7  Location: Chr10:80948624-81014945 bp, - strand  Genetic Position: Chr10, 39.72 cM
Ablation of medium-spiny projection neurons in the striatum of Gng7tm2(cre/PGR)Mmsh/Gng7+ Eno2tm1(DTA)Hsak/Eno2+ mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:145152
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    induced by RU486 (mifepristone)
Mutation:    Insertion
Mutation detailsAn inducible cre cassette consisting of mammalian optimized cre fused to the human progesterone receptor followed by a neo selection cassette in the inverse orientation were inserted into the translation initiation site via homologous recombination. Following RU-496 treatment no Cre activity was detected in brain slices. (J:145152)
Generation of the Gng7tm1(cre)Mmsh and Gng7tm2(cre/PGR)Mmsh alleles
 Tissue activity of this recombinase allele
Driver: Gng7     Summary of all recombinase alleles driven by Gng7.

View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gng7 Mutation:  66 strains or lines available
Original:  J:145152 Kishioka A, et al., A novel form of memory for auditory fear conditioning at a low-intensity unconditioned stimulus. PLoS One. 2009;4(1):e4157
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory