Pold1^tm1.1Uchi
Targeted Allele Detail

Summary

• Symbol: Pold1^tm1.1Uchi
• Name: polymerase (DNA directed), delta 1, catalytic subunit; targeted mutation 1.1, Arikuni Uchimura
• MGI ID: MGI:3833575
• Synonyms: Pold1^exo
• Gene: Pold1 Location: Chr7:44182168-44198239 bp, - strand Genetic Position: Chr7, 28.83 cM
• Alliance: Pold1^tm1.1Uchi page

Tumors arise in Pold1^tm1Uchi/Pold1^tm1.1Uchi mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144992
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

Allele Type: Targeted (Null/knockout) Mutation: Insertion Mutation details: Pold1 mice were crossed to transgenic mice expressing Tg(Sycp1-cre)1Uchi. Germline expression of cre results in excision of the SV40 splice/polyadenylation signal and neomycin resistance cassette. The resulting allele codes for protein in which 3'-5' exonuclease activity is deficient. (J:144992)

Generation of Pold1^tm1Uchi and Pold1^tm1.1Uchi alleles

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Pold1 Mutation: 62 strains or lines available

References

• Original: J:144992 Uchimura A, et al., DNA polymerase delta is required for early mammalian embryogenesis. PLoS One. 2009;4(1):e4184
• All: 2 reference(s)