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Pold1tm1.1Uchi
Targeted Allele Detail
Summary
Symbol: Pold1tm1.1Uchi
Name: polymerase (DNA directed), delta 1, catalytic subunit; targeted mutation 1.1, Arikuni Uchimura
MGI ID: MGI:3833575
Synonyms: Pold1exo
Gene: Pold1  Location: Chr7:44182168-44198239 bp, - strand  Genetic Position: Chr7, 28.83 cM
Alliance: Pold1tm1.1Uchi page
Tumors arise in Pold1tm1Uchi/Pold1tm1.1Uchi mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:144992
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsPold1 mice were crossed to transgenic mice expressing Tg(Sycp1-cre)1Uchi. Germline expression of cre results in excision of the SV40 splice/polyadenylation signal and neomycin resistance cassette. The resulting allele codes for protein in which 3'-5' exonuclease activity is deficient. (J:144992)
Generation of Pold1tm1Uchi and Pold1tm1.1Uchi alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Pold1 Mutation:  48 strains or lines available
References
Original:  J:144992 Uchimura A, et al., DNA polymerase delta is required for early mammalian embryogenesis. PLoS One. 2009;4(1):e4184
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory