Cdk6^tm1.1Phin
Targeted Allele Detail

Summary

• Symbol: Cdk6^tm1.1Phin
• Name: cyclin dependent kinase 6; targeted mutation 1.1, Philip Hinds
• MGI ID: MGI:3833566
• Synonyms: Cdk6-WTdelta
• Gene: Cdk6 Location: Chr5:3391485-3581008 bp, + strand Genetic Position: Chr5, 2.04 cM, cytoband A2-A3
• Alliance: Cdk6^tm1.1Phin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144975
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (No functional change)
• Mutation: Insertion
• Mutation details: Germ line, cre-mediated recombination was used to remove the floxed STOP cassette restoring wild-type expression. (J:144975)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdk6 Mutation: 39 strains or lines available

References

• Original: J:144975 Hu MG, et al., A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis. Cancer Res. 2009 Feb 1;69(3):810-8
• All: 3 reference(s)