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Tg(Thy1-MAPT*K369I)K3Gotz
Transgene Detail
Nomenclature
Symbol: Tg(Thy1-MAPT*K369I)K3Gotz
Name: transgene insertion K3, Jurgen Gotz
MGI ID: MGI:3833383
Synonyms: K3
Transgene: Tg(Thy1-MAPT*K369I)K3Gotz  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F2
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Thy1-MAPT*K369I)K3Gotz expresses 1 gene
 
Mutation detailsThe promoter was used to drive neuron-specific expression of a mutated human cDNA lacking exon 3, containing four microtubule binding domains, and nucleotide substitutions that result in an amino acid substitution of isoleucine for lysine at position 369(K369). One line was created (K3). (J:143439)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:143439 Ittner LM, et al., Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15997-6002
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory