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Tg(CMV-TOR1A*)2Nush
Transgene Detail
Summary
Symbol: Tg(CMV-TOR1A*)2Nush
Name: transgene insertion 2, Nutan Sharma
MGI ID: MGI:3832953
Synonyms: hMT2
Transgene: Tg(CMV-TOR1A*)2Nush  Location: unknown  
Alliance: Tg(CMV-TOR1A*)2Nush page
Transgene
origin
Strain of Origin:  (C57BL/6 x C3H)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(CMV-TOR1A*)2Nush expresses 1 gene
 
Mutation detailsThe promoter was used to drive ubiquitous expression of a human cDNA containing a 3 bp deletion (delta GAG) identified in patients with DYT1 dystonia. Two lines were created (hMT1 and hMT2) with a 2-fold and 1.2-fold increase in expression levels, respectively. (J:98716)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:98716 Sharma N, et al., Impaired motor learning in mice expressing torsinA with the DYT1 dystonia mutation. J Neurosci. 2005 Jun 1;25(22):5351-5
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory