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Mssq18KK
QTL Variant Detail
Nomenclature
QTL variant: Mssq18KK
Name: mandible size and shape QTL 18; KK
MGI ID: MGI:3832947
QTL: Mssq18  Location: unknown  Genetic Position: Chr14, Syntenic
Variant
origin
Strain of Specimen:  KK.Cg-Ay/TaJcl
Variant
description
Allele Type:    QTL
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Notes
Mssq18 interacts with Mssq6 on chromosome 6. Homozygosity for KK- or C57BL/6JJcl-derived alleles at Mssq18 in conjunction with homozygous C57BL/6JJcl-derived alleles at Mssq6 confer decreased mandible size. Heterozygosity at both Mssq6 and Mssq18 significantly increases mandible size.

Mapping and Phenotype information for this QTL, its variants and associated markers

(J:143893)
Genetic loci affecting mandible size and shape were mapped using 190 mice from a (C57BL/6JJcl x KK-A/TaJcl)F2 intercross. Of the F2 population, 97 animals had the A/a genotype and 93 animals had the a/a genotype. Thirteen measurements taken from the right mandible and 3 principal components were assessed in experimental animals 6-7 months of age. Parental strain KK-A/TaJcl displays increased values across most of the 13 mandible measurements compared to parental strain C57BL/6JJcl. The A allele increases mandible size in KK animals compared to the a allele. A panel of 100 polymorphic markers was used for linkage analysis.

Mssq18 (mandible size and shape QTL 18) at 10 cM on mouse Chromosome 14 was identified as an interacting locus with Mssq6 on chromosome 6. Mssq18 maps near D14Mit44. Homozygosity for KK- or C57BL/6JJcl-derived alleles at Mssq18 in conjunction with homozygous C57BL/6JJcl-derived alleles at Mssq6 confer decreased mandible size. Heterozygosity at both Mssq6 and Mssq18 significantly increases mandible size. This interaction is statistically significant (LOD=3.7).

Mssq18 also interacts with Mssq19 on chromosome 16. Homozygous C57BL/6JJcl-derived alleles at Mssq18 in conjunction with homozygous KK-derived alleles at Mssq19 confers significantly increased mandible size measurements. This interaction is statistically significant (LOD=6.7).

References
Original:  J:143893 Suto J, Identification of multiple quantitative trait loci affecting the size and shape of the mandible in mice. Mamm Genome. 2009 Jan;20(1):1-13
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory