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QTL Variant Detail
QTL variant: Mssq13KK/TaJcl
Name: mandible size and shape QTL 13; KK/TaJcl
MGI ID: MGI:3832902
QTL: Mssq13  Location: unknown  Genetic Position: Chr13, Syntenic
Strain of Specimen:  KK.Cg-Ay/TaJcl
Allele Type:    QTL
Mutation:    Undefined
Mutation detailsThis allele confers increased values for principal component assessment of mandible size compared to C57BL/6JJcl. (J:143893)
View phenotypes for all genotypes (concatenated display).
Mapping and Phenotype information for this QTL, its variants and associated markers

Genetic loci affecting mandible size and shape were mapped using 190 mice from a (C57BL/6JJcl x KK-Ay/TaJcl)F2 intercross. Of the F2 population, 97 animals had the Ay/a genotype and 93 animals had the a/a genotype. Thirteen measurements taken from the right mandible and 3 principal components were assessed in experimental animals 6-7 months of age. Parental strain KK-Ay/TaJcl displays increased values across most of the 13 mandible measurements compared to parental strain C57BL/6JJcl. The Ay allele increases mandible size in KK animals compared to the a allele. A panel of 100 polymorphic markers was used for linkage analysis.

Mssq13 (mandible size and shape QTL 13) mapped to 9 cM on mouse Chromosome 13 near D13Mit207 (LOD=5.3 for principal component 2 (PC2); LOD=4 for individual mandible size measurement) in the combined F2 population. KK-derived alleles at Mssq13 confer increased PC2 values for mandible size while C57BL/6JJcl-derived alleles confer increased mandible size measurements. Mssq13 was also detected in the Ay/a F2 group (LOD=2.6) and the a/a F2 group (LOD=2.3). Manln13 (11 cM) is a previously identified QTL located near Mssq13. Edn1 (23 cM) is a potential candidate gene for Mssq13.

Original:  J:143893 Suto J, Identification of multiple quantitative trait loci affecting the size and shape of the mandible in mice. Mamm Genome. 2009 Jan;20(1):1-13
All:  1 reference(s)

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