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QTL Variant Detail
QTL variant: Mssq12KK/TaJcl
Name: mandible size and shape QTL 12; KK/TaJcl
MGI ID: MGI:3832900
QTL: Mssq12  Location: unknown  Genetic Position: Chr12, Syntenic
Strain of Specimen:  KK.Cg-Ay/TaJcl
Allele Type:    QTL
Mutation:    Undefined
Mutation detailsThis allele confers increased values for principal component assessment of mandible size compared to C57BL/6JJcl. (J:143893)
View phenotypes for all genotypes (concatenated display).
Mapping and Phenotype information for this QTL, its variants and associated markers

Genetic loci affecting mandible size and shape were mapped using 190 mice from a (C57BL/6JJcl x KK-Ay/TaJcl)F2 intercross. Of the F2 population, 97 animals had the Ay/a genotype and 93 animals had the a/a genotype. Thirteen measurements taken from the right mandible and 3 principal components were assessed in experimental animals 6-7 months of age. Parental strain KK-Ay/TaJcl displays increased values across most of the 13 mandible measurements compared to parental strain C57BL/6JJcl. The Ay allele increases mandible size in KK animals compared to the a allele. A panel of 100 polymorphic markers was used for linkage analysis.

Significant linkage to principal component 3 (PC3) mapped to two positions on mouse Chromosome 12 in the combined F2 population. Mssq11 (mandible size and shape QTL 11) is located at 13 cM near D12Mit136 (LOD=5.2) and Mssq12 (mandible size and shape QTL 13) is located at 38 cM near D12Mit158. KK-derived alleles at both QTL confer increased PC3 values for mandible size. This locus also displays suggestive linkage to PC3 in the Ay/a F2 group (LOD=2.5). Gsc (52 cM) is a possible candidate gene for Mssq12.

Original:  J:143893 Suto J, Identification of multiple quantitative trait loci affecting the size and shape of the mandible in mice. Mamm Genome. 2009 Jan;20(1):1-13
All:  1 reference(s)

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