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QTL Variant Detail
QTL variant: Mssq9C57BL/6JJcl
Name: mandible size and shape QTL 9; C57BL/6JJcl
MGI ID: MGI:3832893
QTL: Mssq9  Location: unknown  Genetic Position: Chr9, Syntenic
Strain of Specimen:  C57BL/6JJcl
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased mandible size compared to KK/TaJcl. (J:143893)
View phenotypes for all genotypes (concatenated display).
Mapping and Phenotype information for this QTL, its variants and associated markers

Genetic loci affecting mandible size and shape were mapped using 190 mice from a (C57BL/6JJcl x KK-A/TaJcl)F2 intercross. Of the F2 population, 97 animals had the A/a genotype and 93 animals had the a/a genotype. Thirteen measurements taken from the right mandible and 3 principal components were assessed in experimental animals 6-7 months of age. Parental strain KK-A/TaJcl displays increased values across most of the 13 mandible measurements compared to parental strain C57BL/6JJcl. The A allele increases mandible size in KK animals compared to the a allele. A panel of 100 polymorphic markers was used for linkage analysis.

Mssq9 (mandible size and shape QTL 9) mapped to 61 cM on mouse Chromosome 9 near D9Mit212 in the combined F2 population.C57BL/6JJcl-derived alleles at Mssq9 confer increased mandible size for two mandible measurements. Mssq9 also displays suggestive linkage to mandible size in the a/a F2 group (LOD=2.3) and the A/a F2 group (LOD=2.6).

Original:  J:143893 Suto J, Identification of multiple quantitative trait loci affecting the size and shape of the mandible in mice. Mamm Genome. 2009 Jan;20(1):1-13
All:  1 reference(s)

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