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Tg(Thy1-MAPT*V337M)1Godt
Transgene Detail
Nomenclature
Symbol: Tg(Thy1-MAPT*V337M)1Godt
Name: transgene insertion 1, Michel Goedert
MGI ID: MGI:3832877
Synonyms: TauV337M, Tg(Thy1-MAPT*V337M)1Migo
Transgene: Tg(Thy1-MAPT*V337M)1Godt  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6J x CBA/Ca)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Thy1-MAPT*V337M)1Godt expresses 1 gene
 
Mutation detailsThe promoter was used to drive brain-specific expression of a cDNA that encodes the longest three-repeat human isoform with nucleotide substitutions resulting in the amino acid substitution of methionine for valine at position 337 (V337M). This mutation was originally identified in patients with frontotemporal dementias with Parkinsonism linked to chromosome 17 (FTDP-17). No line information was given. (J:143018)
Phenotypes
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Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:143018 Lambourne SL, et al., Impairments in impulse control in mice transgenic for the human FTDP-17 tauV337M mutation are exacerbated by age. Hum Mol Genet. 2007 Jul 15;16(14):1708-19
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory