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Gt(ROSA)26Sortm3.1(CAG-Il17a)Awai
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm3.1(CAG-Il17a)Awai
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3.1, Ari Waisman
MGI ID: MGI:3832630
Synonyms: Del-IL17Aind
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm3.1(CAG-Il17a)Awai page
Granulocytosis and anemia in Gt(ROSA)26Sortm3.1(CAG-Il17a)Awai/Gt(ROSA)26Sor+ mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:144710
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Gt(ROSA)26Sortm3.1(CAG-Il17a)Awai expresses 1 gene
 
Mutation detailsGerm line, cre-mediated recombination was used to remove the STOP cassette from the Gt(ROSA)26Sortm3Awai allele and allow for expression of IL-17A and EGFP regulated by a CAG promoter. (J:144710)
Generation of the Gt(ROSA)26Sortm3(CAG-Il17a)Awai and Gt(ROSA)26Sortm3.1(CAG-Il17a)Awai alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  935 strains or lines available
References
Original:  J:144710 Haak S, et al., IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice. J Clin Invest. 2009 Jan;119(1):61-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory