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Transgene Detail
Symbol: Tg(Amhr2-Pik3ca*,-GFP)#Lzh
Name: transgene insertion, Lin Zhang
MGI ID: MGI:3832594
Synonyms: PIK3CA-Tg
Transgene: Tg(Amhr2-Pik3ca*,-GFP)#Lzh  Location: unknown  
Tg(Amhr2-Pik3ca*,-GFP)#Lzh/0 females exhibit ovarian surface epithelium hyperplasia

Show the 1 phenotype image(s) involving this allele.

Strain of Origin:  (C57BL/6 x C3H)F1
Transgene Type:    Transgenic (Constitutively active, Inserted expressed sequence)
Mutation:    Insertion
Tg(Amhr2-Pik3ca*,-GFP)#Lzh expresses 1 gene
Mutation detailsThis transgene consists of the mouse Amhr2 promoter driving expression of a constitutively active form of mouse Pik3ca and, following an IRES, GFP. The constitutively active form of Pik3ca was created by the addition of the avian src myristoylation sequence (MGSSKSKPK) to the N terminus of Pik3ca. Twelve founders were generated. This record represents pooled data from multiple founder lines. (J:144834)
The construct to generate Tg(Amhr2-Pik3ca*,-GFP)#Lzh/0 mice
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:144834 Liang S, et al., Expression of activated PIK3CA in ovarian surface epithelium results in hyperplasia but not tumor formation. PLoS One. 2009;4(1):e4295
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
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