Retnla^tm1Mer
Targeted Allele Detail

Summary

• Symbol: Retnla^tm1Mer
• Name: resistin like alpha; targeted mutation 1, Marc E Rothenberg
• MGI ID: MGI:3832583
• Synonyms: Retnla^tm1Dart
• Gene: Retnla Location: Chr16:48662972-48664824 bp, + strand Genetic Position: Chr16, 30.75 cM, cytoband B5
• Alliance: Retnla^tm1Mer page

Retnla^tm1Mer/Retnla^tm1Mer mice exhibit exacerbated Schistosoma mansoni egg-induced pulmonary inflammation

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144927
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

Allele Type: Targeted (Null/knockout) Mutation: Intragenic deletion Mutation details: A cassette containing lacZ and neomycin genes replaced all 4 exons of the gene locus. Gene inactivation was confirmed by failure to detect the protein product in sera of homozygous mice whereas it was readily detectable in the sera of wild-type mice. (J:144927)

Generation of the Retnla^tm1Mer allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Retnla Mutation: 12 strains or lines available

References

• Original: J:144927 Munitz A, et al., Resistin-like molecule alpha enhances myeloid cell activation and promotes colitis. J Allergy Clin Immunol. 2008 Dec;122(6):1200-1207.e1
• All: 13 reference(s)