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Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Frances M Ashcroft
MGI ID: MGI:3832575
Synonyms: floxed Kir6.2-V59M
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Reduction in islet insulin content in Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+ Tg(Ins2-cre)23Herr/0 mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:144715
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, Reporter)
Mutation:    Insertion
Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas expresses 1 gene
Mutation detailsA DNA fragment was replaced by a construct consisting of a splice acceptor, a floxed PGK-neo stop cassette, a mouse genomic DNA encoding Kcnj11 with a V59M mutation, and an frt flanked IRES GFP cassette via homologous recombination. Cre mediated removal of the floxed stop cassette allows for expression of Kcnj11. (J:144715)
Generation of the Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas allele
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  540 strains or lines available
Original:  J:144715 Girard CA, et al., Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes. J Clin Invest. 2009 Jan;119(1):80-90
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory